Name: Flashback Friday: How to Block Breast Cancer's Estrogen-Producing Enzymes
Uploaded: 2022-10-21T19:37:59.000Z
Duration: 4 min 24 s
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"How to Block Breast Cancer's Estrogen-Producing Enzymes"

The vast majority of breast cancers start out hormone dependent,

meaning the primary human estrogen, called estradiol,

plays a crucial role in breast cancer development and progression.

That's one of the reasons why soy food consumption

appears so protective against breast cancer,

because soy phytoestrogens, like genistein, act as estrogen-blockers;

they block the binding of estrogens, like estradiol,

But, wait a second; the majority of breast cancers

What's the point of eating estrogen blockers

It turns out the breast cancer tumors  themselves produce their own estrogen

Estrogens may be formed in breast tumors by multiple pathways.

using the aromatase enzyme or two hydroxysteroid dehydrogenase enzymes,

So, there's two ways to stop breast cancer.

One is to use anti-estrogens, estrogen blockers,

is by using anti-enzymes to prevent the breast cancer

from making all the estrogen in the first place.

And indeed, there are a variety of anti-aromatase drugs in current use.

In fact, inhibiting the estrogen production

than just trying to block the effects of the estrogen,

suggesting that the inhibition of estrogen synthesis

is clinically very important for the treatment

It turns out soy phytoestrogens can do both.

Using ovary cells taken from women undergoing in vitro fertilization,

What about in breast cancer cells though?

Not only suppressing  aromatase activity,

but the other estrogen- producing enzyme too.

Does soy suppress estrogen production in people too?

Well, circulating estrogen levels appear significantly lower

in Japanese women than American white women,

and Japan does have the highest per capita soy food consumption,

Japanese women were randomized to add soymilk to their diet

Estrogen levels did seem to drop about a quarter

Interestingly, when they tried the same experiment in men,

a significant drop in female hormone levels,

These results, though, are in Japanese men and women

that were already consuming soy in their baseline diet;

What happens if you give soymilk to women in Texas?

Since increased estrogen levels are a marker

for high risk for breast cancer, the effectiveness of soy

to reduce estrogen levels may help explain

why Chinese and Japanese women have such low rates of breast cancer.

is that estrogen levels stayed down a month or two

This suggests you don't have to consume soy every day