Hey there! Psst! You could get  turned into a Life Noggin Character!

嘿！你在哪裡？噓！你可以變成一個生命諾金的角色！"。

Seriously! Find The Gleam contest  link in the description to enter!

認真點!在描述中找到The Gleam比賽的鏈接來參加!

Welcome to- No time for the  intro! Everyone get in here  

歡迎來到...沒有時間介紹了!每個人都到這裡來

we've got an important mission team!  The biggest battle we've ever been a  

我們有一個重要的任務小組! 我們有史以來最大的一次戰鬥

part of is in this body! We're probably  protecting someone very high profile!

的一部分是在這個身體裡！我們可能是在保護一個非常高調的人!

Yes, I put the ointment on  Mom, okay, I'm busy right now!

是的，我給媽媽塗了藥膏，好的，我現在正忙著呢!

Here's the Intel I made everything with  

這是我用的英特爾公司的產品

construction paper to better  express myself and the mission.

為了更好地表達我自己和任務，我用了建築紙。

There are over 100 different cancers affecting  organs and tissues throughout the body and there  

有超過100種不同的癌症影響著整個身體的器官和組織，並且有

can be lots of differences between them, like what  caused them, what type of cell they formed from,  

它們之間可能有很多不同之處，比如是什麼原因造成的，它們由什麼類型的細胞形成。

and how severe they are, but they all have one  thing in common. It's the thing that allows them  

以及它們有多嚴重，但它們都有一個共同點。就是讓他們

to grow and spread indefinitely, and if scientists  can find a way to stop it, they could stop cancer!

無限期地增長和擴散，如果科學家們能找到一種方法來阻止它，他們就能阻止癌症!

Inside your cells on the ends of your DNA  are telomeres. These protect the chromosomes  

在你的細胞內，DNA的兩端是端粒。這些端粒保護著染色體

by preventing the ends from fraying or tangling,  but every time the cell divides they get shorter.  

通過防止末端磨損或糾纏，但每次細胞分裂時，它們都會變短。

Eventually, they become too short for the cell to  divide again, so the cell dies. This is actually  

最終，它們變得太短，細胞無法再次分裂，是以細胞死亡。這實際上是

a really useful safety feature especially for  pre-cancerous abnormal cells that could one day  

一個真正有用的安全功能，特別是對於有一天可能發生的癌前異常細胞而言。

turn into cancer, but there are ways to lengthen  the telomere. The main way is with an enzyme  

變成癌症，但是有一些方法可以延長端粒。主要的方法是用一種酶

called telomerase. This molecule is mostly found  in an important type of cell called a stem cell.

稱為端粒酶。這種分子主要存在於一種叫做幹細胞的重要類型的細胞中。

Stem cells need to produce new cells throughout  life and telomerase lets them keep their telomeres  

幹細胞在整個生命過程中需要產生新的細胞，而端粒酶讓它們保持其端粒。

long enough so they can keep doing it, but  sometimes pre-cancerous cells mutate in a way that  

足夠長的時間，所以他們可以繼續做下去，但有時癌前細胞會以一種方式變異，即

allows them to produce telomerase as well. This  is how cancer cells are able to keep dividing so  

讓它們也能產生端粒酶。這就是癌細胞能夠不斷分裂的原因，是以

rapidly! Uh-oh...uh we're getting outnumbered!  Triangle Bob, stop playing the new blockymon  

迅速!呃......呃......我們的人數越來越少了! 三角形的鮑勃，不要再玩新的積木式遊戲了

game and start firing the lasers! In addition  to helping the cancer spread, this constant  

遊戲並開始發射脈衝光!除了幫助癌症擴散外，這種持續的

reproduction also makes it hard to kill! Okay  this is getting out of hand. We have to regroup!

繁殖也使得它很難被殺死!好了，這已經失去控制了。我們必須重新組織!

With each cell division, there are slight  alterations made to the genetic code that  

每一次細胞分裂，都會對遺傳密碼進行細微的改變。

can help the new cells survive a cancer treatment  that would have otherwise killed it. This is why  

可以幫助新細胞在本來會殺死它的癌症治療中倖存下來。這就是為什麼

cancer therapies today usually work for  a while but ultimately fail the patient.

今天的癌症療法通常在一段時間內有效，但最終會使病人失敗。

But scientists have come up with a new strategy.

但科學家們想出了一個新的策略。

Here it is, gang! The Secret weapon!

就在這裡，夥計們！祕密武器!

In order to prevent cancer cells  from lengthening their telomeres  

為了防止癌細胞延長其端粒

and not have to worry about some sneaky,  mutated cells able to survive treatment,  

而不必擔心一些偷偷摸摸的變異細胞能夠在治療中存活。

they have come up with Whole-body Interdiction  of Lengthening of Telomeres, or WILT.

他們想出了全身阻斷延長端粒的方法，即WILT。

With this method, one of the genes that  make telomerase would be removed entirely,  

用這種方法，製造端粒酶的一個基因將被完全刪除。

so no cell could use it. They would  also do the same thing for ALT,  

所以沒有細胞可以使用它。他們也會對ALT做同樣的事情。

which is another system cancer cells  use to keep their telomeres long.

這是另一個癌細胞用來保持其端粒長度的系統。

Okay! Okay! The cancer cells are dying!  This is good! Of course that means that  

好了!好了！癌細胞正在死亡！ 這是好的！當然，這意味著

stem cells would eventually die off too,  but they could be replaced every so often,  

幹細胞最終也會死亡，但它們可以每隔一段時間就被替換。

and maybe even with engineered versions that  have longer telomeres, but still no working  

甚至可能是具有較長端粒的工程版本，但仍然沒有工作。

telomerase or ALT! While this strategy may  seem extreme, cancer is an extreme disease,  

端粒酶或ALT!雖然這種策略可能看起來很極端，但癌症是一種極端的疾病。

claiming over 600,000 lives each year, and as  scientists knocked down death rates from more  

每年有超過600,000人喪生，而隨著科學家們將死亡率從更高的水準降低到更低的水準。

and more diseases of Aging, cancer will become  even more threatening if something revolutionary  

和更多的老齡化疾病，如果有革命性的東西，癌症將變得更加具有威脅性。

isn't done. A solution like WILT could help  finally put an end to this devastating disease!

還沒有完成。像WILT這樣的解決方案可以幫助最終結束這種毀滅性的疾病！"。

If you want to learn more about WILT check  out our amazing sponsor of this video SENS  

如果你想了解更多關於WILT的資訊，請查看我們這個視頻的驚人贊助商SENS。

Research Foundation. Click the first  Link in the description right now to  

研究基金會。現在就點擊描述中的第一個鏈接。

support the incredible work that they do.  So, have you or someone you've known been  

支持他們所做的不可思議的工作。 那麼，你或你認識的人是否已經

affected by cancer? If you're comfortable  with sharing let us know your story in the  

受癌症影響的人？如果你願意分享，讓我們知道你的故事在

comments below. It might help someone else  struggling. Be respectful when responding!

下面的評論。它可能會幫助其他正在掙扎的人。迴應時要尊重他人!

Click here to watch this video we did on the  

點擊這裡觀看我們做的這個視頻。

issues with getting older or click  here to watch this video on LSD!

老年人的問題或點擊這裡觀看這個關於LSD的視頻!

Subscribe and click the Bell so  you're notified every time we  

訂閱並點擊鈴鐺，這樣你就會在每次我們的活動中收到通知。

upload a new video and click the like  button because it really helps us out!

上傳一個新的視頻，並點擊喜歡按鈕，因為這真的有助於我們的工作!

You can also check out the team at lifespan  that powers life Noggin down in the description.

你也可以在描述中查看為生命諾金提供動力的壽命團隊。

As always my name is Blocko, this has been  life Noggin, don't forget to keep on thinking!

像往常一樣，我的名字是Blocko，這已經是生活中的Noggin，別忘了繼續思考！我的名字是Blocko。