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  • Hi - this is Kate from MinuteEarth.

  • In the United States alone, 22 people die every day waiting for a kidney, liver, heart,

  • or lung transplant.

  • There simply aren't enough donated human organs to go around, and we can't just go

  • around stealing them out of random healthy people.

  • But pigs' organs have roughly the same structure and proportions as human organsand we

  • already kill half a billion of the creatures every year for foodso why can't we

  • just use their organs?

  • Here's the thing - our immune systems are really, really good at seeking out and destroying

  • anything foreign to our bodies, so even human-to-human organ transplants sometimes get rejected.

  • And pig organs are much foreign-er: they have a super-conspicuous sugar molecule on the

  • surface of their cells that's basically a “fight mesign for humans' organ-rejecting

  • antibodies.

  • But we've actually been able to engineer pigs whose organs don't carry those sugars, so

  • assuming we could take care of pig organs' otherfight mesigns in similar ways,

  • we might one day be able to transplant pig organs into humans.

  • But there's a far more radical idea for pork-based organ farming: grow customized human organs

  • in pigs.

  • Actually, it's not just an ideait's an ongoing experiment in real life.

  • First, we engineer a pig embryo that doesn't grow its own kidneys.

  • Then, we inject it with stem cells from the person needing a transplant.

  • Then, as the modified pig embryo develops, those human cells grow inside the oinkubator

  • into healthy kidneys made from the patient's own cells.

  • At least, that's the plan.

  • So far, we've only seen this experiment all the way through when the modified pig

  • embryos were injected with stem cells from other pigs.

  • We don't know whether it'll actually work with human kidneys, because we've halted

  • all experiments with the pig-human embryos after just four weeks of development, because...some

  • of those human stem cells could develop into other human organs elsewhere in the pig's

  • body - which raises a lot of ethical questions, like what to do with them.

  • Even if the cells don't migrate and these hybrid pigs end up producing lots of live-saving

  • organs, what rights do we give to a part-human pig, even if the part is just a kidney?

  • What if it's two kidneys?

  • Two kidneys, a liver, and a set of lungs?

  • In principle, we could use the same technology to grow human hearts, human spinal cords,

  • and even human brains - all inside of a pig.

  • And when we do, how will we know if that pig is still a pig?

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Hi - this is Kate from MinuteEarth.

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