Subtitles section Play video Print subtitles Hi - this is Kate from MinuteEarth. In the United States alone, 22 people die every day waiting for a kidney, liver, heart, or lung transplant. There simply aren't enough donated human organs to go around, and we can't just go around stealing them out of random healthy people. But pigs' organs have roughly the same structure and proportions as human organs – and we already kill half a billion of the creatures every year for food – so why can't we just use their organs? Here's the thing - our immune systems are really, really good at seeking out and destroying anything foreign to our bodies, so even human-to-human organ transplants sometimes get rejected. And pig organs are much foreign-er: they have a super-conspicuous sugar molecule on the surface of their cells that's basically a “fight me” sign for humans' organ-rejecting antibodies. But we've actually been able to engineer pigs whose organs don't carry those sugars, so assuming we could take care of pig organs' other “fight me” signs in similar ways, we might one day be able to transplant pig organs into humans. But there's a far more radical idea for pork-based organ farming: grow customized human organs in pigs. Actually, it's not just an idea – it's an ongoing experiment in real life. First, we engineer a pig embryo that doesn't grow its own kidneys. Then, we inject it with stem cells from the person needing a transplant. Then, as the modified pig embryo develops, those human cells grow inside the oinkubator into healthy kidneys made from the patient's own cells. At least, that's the plan. So far, we've only seen this experiment all the way through when the modified pig embryos were injected with stem cells from other pigs. We don't know whether it'll actually work with human kidneys, because we've halted all experiments with the pig-human embryos after just four weeks of development, because...some of those human stem cells could develop into other human organs elsewhere in the pig's body - which raises a lot of ethical questions, like what to do with them. Even if the cells don't migrate and these hybrid pigs end up producing lots of live-saving organs, what rights do we give to a part-human pig, even if the part is just a kidney? What if it's two kidneys? Two kidneys, a liver, and a set of lungs? In principle, we could use the same technology to grow human hearts, human spinal cords, and even human brains - all inside of a pig. And when we do, how will we know if that pig is still a pig? This episode of MinuteEarth is supported in part by Tab for a Cause. If you're like me, you open a lot of tabs in your browser. Tab for a Cause is a browser extension that donates to charity with each new tab you open, which means lots of money for nonprofits like Conservation International and Human Rights Watch - without costing you a thing. The last time we featured Tab for a Cause, MinuteEarthings like you raised more than $10,000 - click the link in the description to help us do even better this time. And while you're down there, will you find the notification bell next to the subscribe button, and click on it? YouTube has changed the way it notifies subscribers, and this is the best way to make sure you find out when we post a new video. You can do the same thing on your phone or tablet. If you don't see the bell, make sure you're subscribed in the first place. Thanks, and see you next time!
B2 US pig human tab transplant organ grow Should We Grow Human Organs In Pigs? 142 12 April Lu posted on 2018/08/13 More Share Save Report Video vocabulary