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  • Over the course of our lifetimes,

  • our bodies undergo a series of extraordinary metamorphoses:

  • we grow,

  • experience puberty,

  • and many of us reproduce.

  • Behind the scenes,

  • the endocrine system works constantly to orchestrate these changes.

  • Alongside growth and sexual maturity,

  • this system regulates everything from your sleep

  • to the rhythm of your beating heart,

  • exerting its influence over each and every one of your cells.

  • The endocrine system relies on interactions

  • between three features to do its job:

  • glands,

  • hormones,

  • and trillions of cell receptors.

  • Firstly, there are several hormone-producing glands:

  • three in your brain,

  • and seven in the rest of your body.

  • Each is surrounded by a network of blood vessels,

  • from which they extract ingredients to manufacture dozens of hormones.

  • Those hormones are then pumped out in tiny amounts,

  • usually into the bloodstream.

  • From there, each hormone needs to locate a set of target cells

  • in order to bring about a specific change.

  • To find its targets, it's helped along by receptors,

  • which are special proteins inside or on the cell's surface.

  • Those receptors recognise specific hormones as they waft by,

  • and bind to them.

  • When this happens,

  • that hormone-receptor combination triggers a range of effects

  • that either increase or decrease specific processes inside the cell

  • to change the way that cell behaves.

  • By exposing millions of cells at a time

  • to hormones in carefully-regulated quantities,

  • the endocrine system drives large-scale changes across the body.

  • Take, for instance, the thyroid and the two hormones it produces,

  • triiodothyronine and thyroxine.

  • These hormones travel to most of the body's cells,

  • where they influence how quickly those cells use energy

  • and how rapidly they work.

  • In turn, that regulates everything from breathing rate

  • to heartbeat,

  • body temperature,

  • and digestion.

  • Hormones also have some of their most visibleand familiareffects

  • during puberty.

  • In men, puberty begins when the testes start secreting testosterone.

  • That triggers the gradual development of the sexual organs,

  • makes facial hair sprout,

  • and causes the voice to deepen

  • and height to increase.

  • In women, estrogen secreted from the ovaries signals the start of adulthood.

  • It helps the body develop,

  • makes the hips widen,

  • and thickens the womb's lining,

  • preparing the body for menstruation or pregnancy.

  • An enduring misconception around the endocrine system

  • is that there are exclusively male and female hormones.

  • In fact, men and women have estrogen and testosterone,

  • just in different amounts.

  • Both hormones play a role in pregnancy, as well,

  • alongside more than 10 other hormones that ensure the growth of the fetus,

  • enable birth,

  • and help the mother feed her child.

  • Such periods of hormonal change are also associated with fluctuations in mood.

  • That's because hormones can influence

  • the production of certain chemicals in the brain, like serotonin.

  • When chemical levels shift, they may cause changes in mood, as well.

  • But that's not to say that hormones have unlimited power over us.

  • They're frequently viewed as the main drivers of our behavior,

  • making us slaves to their effects, especially during puberty.

  • But research shows that our behavior is collectively shaped

  • by a variety of influences,

  • including the brain and its neurotransmitters,

  • our hormones,

  • and various social factors.

  • The primary function of the endocrine system

  • is to regulate our bodily processes, not control us.

  • Sometimes disease,

  • stress,

  • and even diet can disrupt that regulatory function, however,

  • altering the quantity of hormones that glands secrete

  • or changing the way that cells respond.

  • Diabetes is one of the most common hormonal disorders,

  • occurring when the pancreas secretes too little insulin,

  • a hormone that manages blood sugar levels.

  • And hypo- and hyperthyroidism

  • occur when the thyroid gland makes too little or too much thyroid hormone.

  • When there's too little thyroid hormone, that results in a slowed heart rate,

  • fatigue,

  • and depression,

  • and when there's too much thyroid hormone,

  • weight loss,

  • sleeplessness,

  • and irritability.

  • But most of the time,

  • the endocrine system manages to keep our bodies in a state of balance.

  • And through its constant regulation,

  • it drives the changes that ultimately help us become who we are.

Over the course of our lifetimes,

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