without the distracting lights at the club

or the mood lighting of the bar,

we have noticed some peculiar things

about our face as we drink.

- So we decided to do a little research,

try a little experiment

and figure out why and how alcohol changes your face.

- Here are the rules of our experiment.

We are going to drink for 12 hours.

One drink every hour.

That might not seem like a lot to some people

but we are for sure lightweights.

We will take photos of our face

every three hours during the day

as we drink and one tomorrow morning

to see how alcohol changes our faces.

We are going to copy our day from yesterday,

the same amount of coffee, same two liters of water,

same veggie meals and snack,

one half-hour workout, our nightly one hour walk

and we already took photos every three hours yesterday

to compare our sober photos

from then to the drunk ones we take today.

Don't try this at home.

Oh, okay.

You're ready.

(foreign language)

- [Mitch] Where'd you learn that?

- I don't know.

I think I saw it once in a movie Ratatouille probably.

See you later, bud.

Oh.

- Okay.

Yeah.

Oh, from now on all

of our drinks will be measured to be around the same amount.

So if we have a shot of liquor

it'll be around 45 milliliters at 40% alcohol.

If we have a glass of wine,

it will be around 150 milliliters at 12%.

And if we have beer or cider

it'll be around 350 milliliters at 5% alcohol.

Cheers.

And I already have to pee.

See you in a minute.

- According to my understanding of biological pathways

it's probably not the alcohol, but I have to shit.

- [Mitch] Ooh, drink number two.

- We have got the good grapes

from a local brewery here in Toronto.

- [Mitch] Ooh look at these glasses.

- We got a Mariah Carey.

Then we got a Charles Darwin,

who we're also gonna fill up

'cause Charles Darwin, as we all know was the bottom.

- This is the first time I'm having a beer type thing

before noon.

With many more drinks to come,

we thought it would be fun to try

and explain the science of alcohol

or getting progressively more drunk through the day.

- Now you know how we make our videos.

So what is happening in your body right now?

Alcohol is absorbed into your bloodstream

through the GI tract and starts getting absorbed

in your stomach, which is why it can hit so fast.

The alcohol molecule then moves through your blood

to the brain and central nervous system

and changes how your neurons or brain cells communicate.

You have two important neurotransmitters in the body.

Glutamate, which affects excitatory neurons

and GABA, which affects inhibitory neurons.

It turns out alcohol suppresses the excitatory

neurotransmitter glutamate,

and increases the inhibitory neurotransmitter GABA,

which causes information flow to become slow,

causing you to feel less, perceive less, notice less

and remember less.

The increased GABA hushes the background noise of activity,

clarifying your thoughts to an excessive degree.

You think less with great clarity.

Hence you're like this dog is amazing.

Essentially alcohol makes you think clearly about nothing.

- Guess what?

I have to pee.

- I haven't peed yet.

I'm sick or are you sick?

- I wanna know your most iconic drunk story.

- I was drunk a lot in my youth.

I was in university,

I learned the bad romance dance.

You know the part, which she goes on the floor

and she puts her leg up.

Oh my God, whole bar watching me leg up everything.

But I also was a university student,

didn't have very much money.

I had the same emo tight black pants,

with a huge rip in the crotch.

As I lift my leg up, my balls fall out.

Like hold mid Lady Gaga dance routine out of the bar.

Yeah I got kicked out for my balls

falling out on a dance floor.

- I have to pee.

- [Greg] Time for the first photo.

Do you feel like your face is different?

- Um no, I actually feel like it's harder

not to smile right now.

While the first few drinks were fun,

things started to unravel.

What just happened?

Tell everyone.

- I forgot I had therapy.

(both laughing)

- I am starting to feel sick.

My body is, my brain's still having fun

but my body is starting to feel not so great.

And we're only halfway through.

- Ugh I hate this.

- I can literally feel my hangover starting.

Gotta pee BRB.

- [Mitch] What are you doing?

- I'm looking at TikTok aren't we all?

- [Mitch] Yes, you're turning red.

It's happening, the flush.

Greg's classic red face meant it was time

for some more drunk science.

- [Greg] Three, two, one go.

- Now the reason I may be feeling a little bit sick

and Greg may have a bit of a red face is

because of complex biochemistry in our bodies.

Alcohol is processed in the liver where enzymes

break down the alcohol into acetaldehyde.

Acetaldehyde is 10 to 30 times more toxic

than alcohol leading to the headaches

and nausea we feel while drinking.

In order to get rid of, and excrete the alcohol byproduct

of acetaldehyde,

it needs to be converted to acetate by glutathione

of which there's only a finite amount.

East Asian people have a gene variant that leads

to higher levels of acetol aldehyde

causing increased sickness and potential for red face.

Greg's not East Asian, obviously

and likely his right face is for a different reason.

Studies have found that British, Irish

and Indigenous Americans get alcohol redness

due to changes in metabolism of vasoactive amines

such as histamines,

which cause vasodilation of blood vessels

in the face and can also lead to inflammation of the face.

So we will see what happens

to Greg's British ass face later on tonight

slash in the morning.

- Why did you just talk about my face there bro?

It was similar to what we had in India.

- Oh my God. - [Mitch] Okay.

Oh, it looked at your butt crack.

- Wait really is my butt out?

- [Mitch] No.

- There's nothing more unattractive than a butt crack.

- [Mitch] A little like hot pink like underwear though.

- Really?

So we are here at Dosa.

If you're in Toronto, come here it's so amazing.

I feel like I'm James Charles.

It is so amazing.

We ate here yesterday for dinner,

we're eating it again for dinner today.

I am drunk and I honestly just love this restaurant

and I want people to come here.

- Love Dosa.

- We're at 11% alcohol.

So I'm gonna go a bit over 150.

If you are around, people have like classist ideologists,

they'll say it's skin contact natural wine.

I love wine that looks like a hangover piece.

- It's six o'clock we've had nine drinks.

- Yeah, alcohol made out of potatoes.

Potatoes!

Do you have agua congas?

Congas.

- You ready to have a sip or do I have a suck?

- Hang on girl.

It's your life, I'm just living in it.

- [Mitch] At this point, things got a bit weird.

We're just gonna leave this here.

(upbeat music)

(slow music)

(rock music)

(upbeat music)

(rock music)

Yeah, we decided to do one final drunk science

on why alcohol makes you pee.

- Is Bio chemistry 101.

- Part one is that I've just consumed so much liquid today.

But on top of that, there's another factor.

There's another factor. - Oh factor.

- Your kidneys. - They're really cute huh?

- They're so cute.

Your kidneys is where your body decides to reabsorb water.

You are dehydrated is gonna to reabsorb more water

so that you stay hydrated.

Antidiuretic hormone goes to your kidney creates aquaporins.

And these aquaporins are proteins and they reabsorb water,

from your kidneys back into your body.

- So ultimately alcohol has an impact on ADH

by decreasing it.

(laughing)

When you drink, your body doesn't have the same mechanism

to save the water.

- Yes.

- And so it just goes through your body in and out.

- And then you pee all potassium, UPF sugars.

- We will relate to tomorrow morning

when we are H-U-N-G over because-

- I thought you were gonna lean over and say hung.

And I'm going to say, "Oh boy!"

- Girl, that's all the time.

- As we made it to the last few drinks,

it got a little rough.

- Okay.

It's become too much for me.

You hate alcohol?

- Yeah, I think it makes me feel not aware of the world.

It makes me not feel present

and we only have like the years we're alive.

I don't want to spend it like this.

- I would not do this again.

- No pictures.

- [Mitch] We're taking a photo now.

- TMZ no.

- [Mitch] Final photos captured.

We went to bed bracing for the morning.

Of course we were so hung over we forgot

to vlog us taking our morning pictures.

- So here we are, a week later.

- It took us that long to recover from the hangover.

- We did not film our hangover 'cause it was disgusting

and depressing.

- I have not been that hung over in a long time

because we don't drink nearly as much anymore.

It hurt.

We are now going to look at our comparison.

(laughing)

- Oh my God.

- Okay.

It is obviously so red, but it's not that bad.

It's actually isn't that bad.

- [Greg] Like I mean, it is for like any other person.

- It's interesting that it happened presumably a lot

at this point in the middle of our drinking

or near the beginning.

- I always find that it's like so frustrating to me.

It's like, when I first get to a party

within the first hour or two, everyone's like,

"Greg you are so red, you look like Santa Clause."

I feel when my, when I drink my face gets hot.

- [Mitch] It's interesting because it's so defined

along this sort of line.

- Okay, I need to not drink, I'm like alert.