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Japanese scientists have recently successfully turned mice translucent.
Hi there viewers, Julian here for DNews. Translucent animals are more common than you probably
think, in that they actually already exist.
Most of the naturally occurring ones are found in the deep ocean. There’s so little light
that reflecting any that does reach that far down can make them a tasty piece of deep sea
horror sushi. So a lot of deep sea critters are see-through to avoid that. You might notice
a lot of them are red or a transparent pink too, because red light’s long wavelength
means it has low energy and doesn’t penetrate water well. Thus animals that only reflect
red light are essentially invisible down there. Isn’t science neat?
Up here there’s not much point in having transparent skin. There’s so much light
that being a gooey see-through blob of floating bones and organs is going to be a bit more
noticeable than being the same color as your surrounds, so it doesn’t really make sense.
Of course scientists aren’t hampered by your precious “logic” and have bred a
few frogs and goldfish to have see through skin. Researchers in Japan took the most pale
ones they could find and kept breeding them together.
The goal is to be able to observe the internal organs while the animal is alive, making it
easier to keep track of tumor growth and how they react to chemicals. This for me raises
an important philosophical question. No it’s not, “should scientists play god?” I want
to know what you call a see through goldfish.
But now there’s a way to turn the skin, brain, lungs, the whole shebang except the
bones clear. A team at the RIKEN quantitative biology center in Osaka pulled off the trick
on mice by flushing out their circulatory systems with saline and then pumping a chemical
through them for 2 weeks.
The chemical removes heme from the mice. Heme is found in most tissue and is the “heme”
part of hemoglobin, it’s the compound in blood that binds to oxygen and also gives
it its red tint. Fun fact: your blood is always red, regardless of whether or not it has oxygen.
Remember what I said about red light not being able to penetrate well because of it’s low
energy? That’s why your veins look blue under your skin.
Totally transparent mice make it possible to see the cellular networks inside tissue.
Hiroki Ueda, who led the team, hopes it can be used to gain a better understanding of
cancer or autoimmune diseases by being able to observe how they develop without having
to dissect the mice.
As it so often goes though, the mice don’t get off easy. Being stripped of blood and
then heme entirely is pretty much game over. But I for one am resting easier knowing that
there’s no nightmare fuel jell-o mice running around with the chance to escape and breed
and form an invisible army of horror and cheese theft.
If you want to learn another way to turn yourself invisible while keeping all your blood in
you, Amy’s got a video on that over here.
If you’ve got a story of a time science did something awesome for lab mice, I want
to hear about it in the comments. I’m not a vegetarian or anything, but I can only read
so many stories about lab mice before I need a pick me up. Until then, I’ll see you next
time on DNews.