AndersoncametofameintheleadroleofAngusmacgyverinthehittelevisionseriesmacgyver, whichlastedfrom 1985 to 1992 andwashighlysuccessfulthroughoutoursevenyearrun.
ThecharacterAngusmacgyverknownasjustMacgyverorMacuntilthefinalseasonwasanoptimisticactionherothatwasnotableforusing a Swissarmyknifeinsteadof a firearmashistoolofchoice.
Latercareerin 1995 hecostarredwithJohnDelanceandLegend, a comicseriesofonly 12 episodesabout a dimenovelwriterwithintheWildWestwhoagainsthiswillhastoplaytheroleofhisownfictionalcharacteroriginallywrittenas a TVmovie.
WiththedecisiontomakeLegend a series, theoriginalteleplaybecamethetwohourpilotepisode.
AndersonwasapplaudedforhisrolesasErnestPrattandNicodemusLegendbymanycritics, mostnotablyJohn o'connorfromTheNewYorkTimesfrom 1997 to 2005.
AndersonterminatedhisstatusasstarandproducerofStargateSGoneoptingtomakeseveralguestappearancehispastseasoninsteadallowinghissizeableroletobefilledbyveteranactors, BenBrowder, ClaudiaBlackandEmmynomineeBeauBridgesattheAirForceAssociation's 57thannualAirForceanniversarydinnerinWashingtonDConSeptember 14th, 2004 thenAirForceChiefofStaffGeneralJohn P DumperpresentedAndersonwithanawardbecauseofhisroleasstarandexecutiveproducerofStargateSGOne, a serieswhichportrayedtheAirForcein a positivelightfromitspremiere.
AndersonwasalsomadeanhonoraryAirForceBrigadierGeneral, a greatfanofthetelevisionshow, TheSimpsons, whichhehadcontinuallyreferencedduringhistimeonSGOne.
LeeDavidslotoffthecreatorofmacgyverannouncedonMay 3rd 2008 that a Macgyverfilmwasinproduction.
Andersonhasexpressedinterestinrevisitinghisrole.
However, thereisnowordonwhowillbeplayingtheroleofMacgyverinthefilmAndersoncameoasMacgyverinwhatseemedtobe a SaturdayNightliveadvertisementparodyfeaturingtheshow's recurringcharacterMacGruber, butwasrather a realcommercialforbothSaturdayNightLiveandPepsiinwhichthetitularcharacterbecomesobsessedwiththesoftdrink.
Andersonis a memberoftheBoardofTrusteesforChallengersBoysandGirlsClub.
A youthorganizationestablishedin 1968 withthehelpofMacgyverproducerStephenDowningandfeaturedinanepisodefromseasonfouroftheshow.
Hereceivedthe 1995 celebrityawardfromtheMake a WishFoundationbecauseofhiscommitmenttothefoundation.
Heisalso a supporterforvarioussclerosissociety, nonprofitorganizationsandhasdoneseveralpublicserviceannouncementstoshowhissupportforthevariousorganizations.